Principal Investigator

Benjamin Kidder, Ph.D.

Principal Investigator

Ben KBenjamin Kidder is an Assistant Professor in the Department of Oncology at Wayne State University and member of the Barbara Ann Karmanos Cancer Institute. His research focuses on epigenetic mechanisms of stem cell self-renewal and differentiation, transcriptional networks, genome stability and cancer epigenetics, and reprogramming and transdifferentiation. Dr. Kidder graduated with honors from Saint Olaf College in Northfield, MN where he majored in Chemistry and Biology, and then performed research at the National Institute of Dental and Craniofacial Research (NIDCR), National Institutes of Health (NIH) as a Postbaccalaureate pre-IRTA Fellow. He received his Ph.D. in Molecular, Cellular, Developmental Biology and Genetics (MCDB&G) from the University of Minnesota in 2007, followed by research as a Postdoctoral Fellow and later as a Principal Investigator at Merck/EMD Serono Research Institute in the greater Boston area. He continued his postdoctoral research in Keji Zhao’s Lab at the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH) in Bethesda, MD.

Selected publications

  • He R, Xhabija B, Gopi LK, Kurup JT, Xu Z, Liu Z, Kidder BL. H3K4 demethylase KDM5B regulates cancer cell identity and epigenetic plasticity. Oncogene. 2022 Apr 19. doi: 10.1038/s41388-022-02311-z. Online ahead of print. PMID: 35440714
  • Kurup JT, Kidder BL. H4K20me3 methyltransferase SUV420H2 shapes the chromatin landscape of pluripotent embryonic stem cells. Development. 2020 Dec 4;147(23):dev188516. doi: 10.1242/dev.188516. PMID: 33144397
  • Gopi LK, Kidder BL. Integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains. Nature Communications. 2021;12(1):1419. doi: 10.1038/s41467-021-21707-1.
  • He R, Kidder BL*. H3K4 demethylase KDM5B regulates global dynamics of transcription elongation and alternative splicing in embryonic stem cells. NUCLEIC ACIDS RESEARCH 2017 April 10. PMID: 28402433 . *Corresponding author
  • Kidder BL*, Hu G, Cui K, Zhao K*. SMYD5 regulates H4K20me3-marked heterochromatin to safeguard ES cell self-renewal and prevent spurious differentiation. EPIGENETICS AND CHROMATIN 2017 Feb 23;10:8. doi: 10.1186/s13072-017-0115-7. PMID: 28250819 *Co-corresponding authors
  • Kidder BL*, Hu G, Zhao K*. KDM5B focuses H3K4 methylation near promoters and enhancers during embryonic stem cell self-renewal and differentiation. GENOME BIOLOGY 2014 Feb 4;15(2):R32 (Epub). PMID: 24495580 *Co-corresponding authors
  • Kidder BL*, Hu G, Yu Z, Liu C, Zhao K*. Extended self-renewal and accelerated reprogramming in the absence of Kdm5b. MOLECULAR AND CELLULAR BIOLOGY 2013 Dec;33(24):4793-810. PMID: 24100015 *Co-corresponding authors
  • Kidder BL*, Hu G, Zhao K*. ChIP-Seq: technical considerations for obtaining high quality data. NATURE IMMUNOLOGY 2011 Sep 20;12(10):918-22. PMID: 21934668 *Co-corresponding authors
  • Kidder BL*, Palmer S. HDAC1 regulates pluripotency and lineage specific transcriptional networks in embryonic and trophoblast stem cells. NUCLEIC ACIDS RESEARCH 2012 Apr;40(7):2925-39. PMID: 22156375 *Corresponding author
  • Kidder BL*, Palmer S. Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance. GENOME RESEARCH 2010 Apr;20(4):458-72. PMID: 20176728 *Corresponding author
  • Kidder BL, Palmer S, Knott JG. SWI/SNF-Brg1 regulates self-renewal and occupies core pluripotency-related genes in embryonic stem cells. STEM CELLS 2009 FEB; 27(2):317-28. PMID: 19056910
  • Kidder BL*, Yang J, Palmer S. Stat3 and c-Myc genome-wide promoter occupancy in embryonic stem cells. PLOS ONE. 2008;3(12):e3932. PMID: 19079543 *Corresponding author
  • Kidder BL, Oseth L, Miller SC, Hirsch B, Verfaillie C, Coucouvanis E. Embryonic stem cells contribute to mouse chimeras in the absence of detetable cell fusion. CLONING STEM CELLS 10 (2): 231-248 JUN 2008. PMID: 18338954
  • Ulloa-Montoya F*, Kidder BL*, Pauwelyn K, Chase L, Luttun A, Crabbe A, Geraerts M, Sharov AA, Piao Y, Ko MS, Hu WS, Verfaillie CM. Comparative transcriptome analysis of embryonic and adult stem cells with extended and limited differentiation capacity. GENOME BIOLOGY 8 (8): R163 2007. PMID: 17683608 *contributed equally
  • Chase LG, Ulloa-Montoya F, Kidder BL, Verfaillie C. Islet-derived fibroblast-like cells are not derived via endoderm-mesoderm transition from Pdx-1 or Insulin positive cells. DIABETES 56 (1): 3-7 JAN 2007. PMID: 17110468
  • Hoffman MP, Kidder BL, Steinberg ZL, Lakhani S, Ho S, Kleinman HK, Larsen M. Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms. DEVELOPMENT 129 (24): 5767-5778 DEC 2002. PMID: 12421715

Book Editorships

Book Chapters

  • Kidder BL. Direct Reprogramming of Mouse Embryonic Fibroblasts to Induced Trophoblast Stem Cells. METHODS IN MOLECULAR BIOLOGY. 2020;2117:285-292. doi: 10.1007/978-1-0716-0301-7_18. PMID: 31960387
  • Kidder BL. Derivation of Maternal Epiblast Stem Cells from Haploid Embryos. METHODS IN MOLECULAR BIOLOGY. 2020;2117:219-227. doi: 10.1007/978-1-0716-0301-7_12. PMID: 31960381
  • Kidder BL. Simultaneous Derivation of Embryonic and Trophoblast Stem Cells from Mouse Blastocysts. METHODS IN MOLECULAR BIOLOGY. 2020;2117:235-241. doi: 10.1007/978-1-0716-0301-7_14. PMID: 31960383
  • Kidder BL. Derivation of LIF-Independent Embryonic Stem Cells Using Inducible OCT4 Expression. METHODS IN MOLECULAR BIOLOGY. 2020;2117:229-234.doi: 10.1007/978-1-0716-0301-7_13. PMID: 31960382
  • Kidder BL*, Zhao K. Efficient library preparation for next-generation sequencing analysis of genome-wide epigenetic and transcriptional landscapes in embryonic stem cells. METHODS IN MOLECULAR BIOLOGY. 2014;1150:3-20. doi:10.1007/978-1-4939-0512-6_1.PMID: 24743988 *Corresponding author
  • Kidder BL. Generation of induced pluripotent stem cells using chemical inhibition and three transcription factors. METHODS IN MOLECULAR BIOLOGY. 2014;1150:227-36. doi: 10.1007/978-1-4939-0512-6_15. PMID: 24744002
  • Kidder BL. Derivation and manipulation of trophoblast stem cells from mouse blastocysts. METHODS IN MOLECULAR BIOLOGY, 2014;1150:201-12. doi: 10.1007/978-1-4939-0512-6_13. PMID: 24744000
  • Kidder BL. In vitro maturation and in vitro fertilization of mouse oocytes and preimplantation embryo culture. METHODS IN MOLECULAR BIOLOGY, 2014;1150:191-9. doi: 10.1007/978-1-4939-0512-6_12. PMID: 2474399